Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N
Data Element Attributes
Identifying and definitional attributes | |
Metadata item type: | Data Element |
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Short name: | Cholesterol—LDL (calculated) |
METEOR identifier: | 270402 |
Registration status: | Health!, Superseded 01/10/2008 |
Definition: | A person's calculated low-density lipoprotein cholesterol (LDL-C). |
Data Element Concept: | Person—low-density lipoprotein cholesterol level |
Value Domain: | Millimoles per litre N[N].N |
Data element attributes | |
Collection and usage attributes | |
Guide for use: | Formula: LDL-C = (plasma total cholesterol) - (high density lipoprotein cholesterol) - (fasting plasma triglyceride divided by 2.2). |
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Collection methods: | The LDL-C is usually calculated from the Friedwald Equation (Friedwald et al. 1972), which depends on knowing the blood levels of the total cholesterol and HDL-C and the fasting level of the triglyceride. Note that the Friedwald equation becomes unreliable when the plasma triglyceride exceeds 4.5 mmol/L. Note also that while cholesterol levels are reliable for the first 24 hours after the onset of acute coronary syndromes, they may be unreliable for the subsequent 6 weeks after an event.
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Comments: | High blood cholesterol is a key factor in heart, stroke and vascular disease, especially coronary heart disease (CHD). Poor nutrition can be a contributing factor to heart, stroke and vascular disease as a population's level of saturated fat intake is the prime determinant of its level of blood cholesterol. The majority of the cholesterol in plasma is transported as a component of LDL-C. Thus, the evidence linking CHD to plasma total cholesterol and LDL-C is essentially the same. |
Source and reference attributes | |
Submitting organisation: | Cardiovascular Data Working Group |
Origin: | National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88. |
Relational attributes | |
Related metadata references: | Has been superseded by Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N Health!, Standard 01/10/2008 Is formed using Health service event—fasting indicator, code N Health!, Standard 21/09/2005 Is formed using Person—cholesterol level (measured), total millimoles per litre N[N].N Health!, Superseded 01/10/2008 Is formed using Person—high-density lipoprotein cholesterol level (measured), total millimoles per litre [N].NN Health!, Standard 01/03/2005 Is formed using Person—triglyceride level (measured), total millimoles per litre N[N].N Health!, Superseded 01/10/2008 Is re-engineered from Cholesterol-LDL calculated, version 1, Derived DE, NHDD, NHIMG, Superseded 01/03/2005 .pdf (19.7 KB) No registration status |
Implementation in Data Set Specifications: | Acute coronary syndrome (clinical) DSS Health!, Superseded 07/12/2005 Acute coronary syndrome (clinical) DSS Health!, Superseded 01/10/2008 Cardiovascular disease (clinical) DSS Health!, Superseded 15/02/2006 DSS specific information: Many studies have demonstrated the significance of blood cholesterol components as risk factors for heart, stroke and vascular disease. Scientific studies have shown a continuous relationship between lipid levels and Coronary Heart Disease (CHD) and overwhelming evidence that lipid lowering interventions reduces CHD progression, morbidity and mortality. There are many large-scale, prospective population studies defining the relationship between plasma total (and Low-density Lipoprotein (LDL)) cholesterol and the future risk of developing CHD. The results of prospective population studies are consistent and support several general conclusions:
The excess non-coronary mortality at low cholesterol levels in the Honolulu Heart Study (Yano et al. 1983; Stemmermann et al. 1991) was apparent only in people who smoked and is consistent with a view that smokers may have occult smoking related disease that is responsible for both an increased mortality and a low plasma cholesterol. It should be emphasised that the prospective studies demonstrate an association between plasma total cholesterol and LDL-C and the risk of developing CHD. (Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88 and Commonwealth Department of Health & Ageing and Australian Institute of Health and Welfare (1999) National Health Priority Areas Report: Cardiovascular Health 1998. AIHW Cat. No. PHE 9. HEALTH and AIHW, Canberra pgs 14-17). In settings such as general practice where the monitoring of a person's health is ongoing and where a measure can change over time, the service contact date should be recorded. Cardiovascular disease (clinical) DSS Health!, Superseded 04/07/2007 DSS specific information: Many studies have demonstrated the significance of blood cholesterol components as risk factors for heart, stroke and vascular disease. Scientific studies have shown a continuous relationship between lipid levels and Coronary Heart Disease (CHD) and overwhelming evidence that lipid lowering interventions reduces CHD progression, morbidity and mortality. There are many large-scale, prospective population studies defining the relationship between plasma total (and Low-density Lipoprotein (LDL)) cholesterol and the future risk of developing CHD. The results of prospective population studies are consistent and support several general conclusions:
The excess non-coronary mortality at low cholesterol levels in the Honolulu Heart Study (Yano et al. 1983; Stemmermann et al. 1991) was apparent only in people who smoked and is consistent with a view that smokers may have occult smoking related disease that is responsible for both an increased mortality and a low plasma cholesterol. It should be emphasised that the prospective studies demonstrate an association between plasma total cholesterol and LDL-C and the risk of developing CHD. (Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88 and Commonwealth Department of Health & Ageing and Australian Institute of Health and Welfare (1999) National Health Priority Areas Report: Cardiovascular Health 1998. AIHW Cat. No. PHE 9. HEALTH and AIHW, Canberra pgs 14-17). In settings such as general practice where the monitoring of a person's health is ongoing and where a measure can change over time, the service contact date should be recorded. Cardiovascular disease (clinical) DSS Health!, Superseded 22/12/2009 DSS specific information: Many studies have demonstrated the significance of blood cholesterol components as risk factors for heart, stroke and vascular disease. Scientific studies have shown a continuous relationship between lipid levels and Coronary Heart Disease (CHD) and overwhelming evidence that lipid lowering interventions reduces CHD progression, morbidity and mortality. There are many large-scale, prospective population studies defining the relationship between plasma total (and Low-density Lipoprotein (LDL)) cholesterol and the future risk of developing CHD. The results of prospective population studies are consistent and support several general conclusions:
The excess non-coronary mortality at low cholesterol levels in the Honolulu Heart Study (Yano et al. 1983; Stemmermann et al. 1991) was apparent only in people who smoked and is consistent with a view that smokers may have occult smoking related disease that is responsible for both an increased mortality and a low plasma cholesterol. It should be emphasised that the prospective studies demonstrate an association between plasma total cholesterol and LDL-C and the risk of developing CHD. (Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88 and Commonwealth Department of Health & Ageing and Australian Institute of Health and Welfare (1999) National Health Priority Areas Report: Cardiovascular Health 1998. AIHW Cat. No. PHE 9. HEALTH and AIHW, Canberra pgs 14-17). In settings such as general practice where the monitoring of a person's health is ongoing and where a measure can change over time, the service contact date should be recorded. |